First responders were called early on Monday to a stretch of the interstate that left at least five people with undisclosed injuries.
Each was taken to an area hospital.
The crash also led to temporary closures in the southbound lanes.
Details about the crash have not been released by state police.
This is a developing story. Check Daily Voice for updates.
Want breaking news in the DMV as it happens, or want to contribute? Join the DMV All Incidents Facebook group.
Click here to follow Daily Voice Boonsboro and receive free news updates.